Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide
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چکیده
منابع مشابه
Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide.
Inflammatory demyelinating neuropathies such as Guillain-Barre syndrome (GBS) and its animal model, experimental autoimmune neuritis (EAN), are typically acute monophasic diseases of the PNS that can leave affected individuals with permanent disability due primarily to axonal degeneration. The mechanisms underlying the degeneration are not understood, but we have previously shown in vitro and i...
متن کاملCorrection: Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection
Fig 2 and Fig 4 are swapped. The image in Fig 2 should be the image in Fig 4 and the image in Fig 4 should be the image in Fig 2. The captions remain unchanged. The publisher apologizes for the error. Please see the corrected Fig 2 and Fig 4 here. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reprod...
متن کاملDimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection
BACKGROUND Dimethyl fumarate is an immunomodulatory and neuroprotective drug, approved recently for the treatment of relapsing-remitting multiple sclerosis. In view of the limited therapeutic options for human acute and chronic polyneuritis, we used the animal model of experimental autoimmune neuritis in the Lewis rat to study the effects of dimethyl fumarate on autoimmune inflammation and neur...
متن کاملSodium channel blockers and axonal protection in neuroinflammatory disease.
Although demyelination is a cardinal feature of neuroinflammatory conditions such as Guillain–Barré syndrome (GBS) and multiple sclerosis, axonal degeneration also occurs in these disorders. Because loss of axons causes permanent, non-remitting loss of neurological function, there is substantial interest in protection of axons in these situations. Protection of axons within white matter and per...
متن کاملSodium channel blockers and axonal protection in neuroinflammatory disease
Although demyelination is a cardinal feature of neuroinflammatory conditions such as Guillain–Barré syndrome (GBS) and multiple sclerosis, axonal degeneration also occurs in these disorders. Because loss of axons causes permanent, non-remitting loss of neurological function, there is substantial interest in protection of axons in these situations. Protection of axons within white matter and per...
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ژورنال
عنوان ژورنال: Brain
سال: 2004
ISSN: 1460-2156
DOI: 10.1093/brain/awh328